INIT models are automatically generated Genome-Scale Metabolic Models for different human cell types. The first version models (r1) were generated for 69 different human cell types [1] whereas the second version models (r2) were generated by a revised algorithm and for 82 different human cell types [2]. For each cell type there is also provide a link to the Human Protein Atlas that provides further description of the human cell type and associated protein expression.
Digestive tract | ||||
---|---|---|---|---|
Oral mucosa | Squamous epithelial cells | r1 | r2 | |
Salivary gland | Glandular cells | r1 | r2 | |
Esophagus | Squamous epithelial cells | r1 | r2 | |
Stomach, upper | Glandular cells | r1 | r2 | |
Stomach, lower | Glandular cells | r1 | r2 | |
Duodenum | Glandular cells | r1 | r2 | |
Small intestine | Glandular cells | r1 | r2 | |
Appendix | Glandular cells | r1 | r2 | |
Appendix | Lymphoid tissue | r1 | r2 | |
Colon | Endothelial cells | - | r2 | |
Colon | Glandular cells | r1 | r2 | |
Colon | Peripheral nerve-ganglion | - | r2 | |
Rectum | Glandular cells | r1 | r2 |
Breast and female reproductive system | ||||
---|---|---|---|---|
Breast | Adipocytes | - | r2 | |
Breast | Glandular cells | r1 | r2 | |
Breast | Myoepithelial cells | - | r2 | |
Vagina | Squamous epithelial cells | r1 | r2 | |
Cervix, uterine | Squamous epithelial cells | r1 | r2 | |
Cervix, uterine | Glandular cells | r1 | r2 | |
Uterus, pre-menopause | Glandular cells | r1 | r2 | |
Uterus, pre-menopause | Cells in endometrial stroma | r1 | r2 | |
Uterus, post-menopause | Glandular cells | r1 | r2 | |
Uterus, post-menopause | Cells in endometrial stroma | r1 | r2 | |
Fallopian tube | Glandular cells | r1 | r2 | |
Ovary | Follicle cells | r1 | r2 | |
Ovary | Ovarian stroma cells | r1 | r2 |
Liver and pancreas | ||||
---|---|---|---|---|
Liver | Hepatocytes | r1 | r2 | |
Liver | Bile duct cells | r1 | r2 | |
Gallbladder | Glandular cells | r1 | r2 | |
Pancreas | Exocrine glandular cells | r1 | r2 | |
Pancreas | Islets of Langerhans | r1 | - |
Male reproductive system | ||||
---|---|---|---|---|
Testis | Cells in seminiferus ducts | r1 | r2 | |
Testis | Leydig cells | r1 | - | |
Epididymis | Glandular cells | r1 | r2 | |
Prostate | Glandular cells | r1 | r2 | |
Seminal vesicle | Glandular cells | r1 | r2 |
Urinary tract | ||||
---|---|---|---|---|
Kidney | Cells in glomeruli | r1 | r2 | |
Kidney | Cells in tubules | r1 | r2 | |
Urinary bladder | Urothelial cells | r1 | r2 |
Placenta | ||||
---|---|---|---|---|
Placenta | Trophoblastic cells | r1 | r2 | |
Placenta | Decidual cells | r1 | r2 |
Skin and soft tissues | ||||
---|---|---|---|---|
Soft tissue 1 | Adipocytes | - | r2 | |
Soft tissue 1 | Chondrocytes | - | r2 | |
Soft tissue 1 | Fibroblasts | - | r2 | |
Soft tissue 1 | Peripheral nerve | r1 | r2 | |
Soft tissue 2 | Adipocytes | - | r2 | |
Soft tissue 2 | Chondrocytes | - | r2 | |
Soft tissue 2 | Fibroblasts | - | r2 | |
Soft tissue 2 | Peripheral nerve | r1 | r2 | |
Skin | Fibroblasts | - | r2 | |
Skin | Keratinocytes | - | r2 | |
Skin | Langerhans | r1 | - | |
Skin | Melanocytes | r1 | r2 | |
Vulva-anal skin | Epidermal cells | r1 | r2 | |
Skeletal muscle | Myocytes | r1 | r2 | |
Smooth muscle | Smooth muscle cells | r1 | r2 |
Central nervous system | ||||
---|---|---|---|---|
Cerebral cortex | Neuronal cells | r1 | r2 | |
Cerebral cortex | Endothelial cells | - | r2 | |
Cerebral cortex | Glial cells | r1 | r2 | |
Cerebral cortex | Neuropil | - | r2 | |
Hippocampus | Neuronal cells | r1 | r2 | |
Hippocampus | Glial cells | r1 | r2 | |
Lateral ventricle | Neuronal cells | r1 | r2 | |
Lateral ventricle | Glial cells | r1 | r2 | |
Cerebellum | Purkinje cells | r1 | - | |
Cerebellum | Cells in granular layer | r1 | r2 | |
Cerebellum | Cells in molecular layer | r1 | r2 |
Blood and immune system | ||||
---|---|---|---|---|
Bone marrow | Hematopoietic cells | r1 | r2 | |
Lymph node | Germinal center cells | r1 | r2 | |
Lymph node | Non-germinal center cells | r1 | r2 | |
Tonsil | Germinal center cells | r1 | r2 | |
Tonsil | Non-germinal center cells | r1 | r2 | |
Tonsil | Squamous epithelial cells | r1 | r2 | |
Spleen | Cells in white pulp | r1 | r2 | |
Spleen | Cells in red pulp | r1 | r2 |
Respiratory system | ||||
---|---|---|---|---|
Nasopharynx | Respiratory epithelial cells | r1 | r2 | |
Bronchus | Respiratory epithelial cells | r1 | r2 | |
Lung | Pneumocytes | r1 | r2 | |
Lung | Macrophages | r1 | r2 |
Endocrine glands | ||||
---|---|---|---|---|
Thyroid gland | Glandular cells | r1 | r2 | |
Parathyroid gland | Glandular cells | r1 | r2 | |
Adrenal gland | Glandular cells | r1 | r2 |
Cardiovascular system | ||||
---|---|---|---|---|
Heart muscle | Myocytes | r1 | r2 |